4EBP1 Monoclonal Antibody (9E12D9), Invitrogen™

Descripción

MA5-15312 targets 4E-BP1 in indirect ELISA, WB applications and shows reactivity with Human samples. The MA5-15312 immunogen is purified recombinant fragment of 4EBP1 expressed in E. Coli.

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E, which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.