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53BP1 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marca: Invitrogen PA534675
Detalles adicionales : Peso : 0.01000kg
Descripción
Recommended positive controls: 293T, HeLa, Neuro 2A, C8D30, NIH-3T3. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
53BP1 (P53-binding protein 1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, 53BP1 is phosphorylated and localizes to the presumptive sites of damage, specifically, double-strand breaks. 53BP1 may have a role in checkpoint signaling during mitosis, enhances TP53-mediated transcriptional activation, and participates in DNA repair by maintaining genomic stability.Especificaciones
| 53BP1 | |
| Polyclonal | |
| Unconjugated | |
| TP53BP1 | |
| 53BP1; FLJ41424; m53BP1; MGC138366; murine p53-binding protein; p202; p53-binding protein 1; p53BP1; TDRD30; TP53; TP53-binding protein 1; Tp53bp1; transformation related protein 53 binding protein 1; transformation related protein 53 binding-protein 1; Trp53bp1; tumor protein 53-binding protein, 1; tumor protein p53 binding protein 1; tumor protein p53-binding protein, 1; tumor suppressor p53-binding protein 1 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 27223, 7158 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot | |
| 1 mg/mL | |
| 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7 | |
| P70399, Q12888 | |
| TP53BP1, Trp53bp1 | |
| Recombinant fragment corresponding to a region within amino acids 1 and 229 of 53BP1 (Uniprot ID#Q12888) | |
| 100 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |