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![Invitrogen Human ABL1 [F317L], GST Tag Recombinant Protein Quantity: 100](https://assets.fishersci.com/TFS-Assets/LSG/product-images/Cell_Bio_Rec_Prot_Invitrogen_Vial.jpg-650.jpg)
Invitrogen™ Human ABL1 [F317L], GST Tag Recombinant Protein
This ABL1 F317L Recombinant Human Protein (27-end) was expressed in insect cells.
Marca: Invitrogen™ A33550
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Descripción
ABL1 cytoplasmic tyrosine kinase protooncogene encodes a cytoplasmic and nuclear kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of ABL protein is negatively regulated by its SH3 domain and deletion of the SH3 domain turns ABL1 into an oncogene. Translocation and head-to-tail fusion of the BCR and ABL1 genes is present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDK1-mediated phosphorylation, suggesting a cell cycle function for ABL1.- Validated for use with the Z’-LYTE™ assay
- Available in multiple pack sizes for convenient use
Especificaciones
| NP_005148.2 | |
| 146.3 kDa | |
| ABL Kinase Family | |
| Human | |
| GST Tag | |
| Dry Ice | |
| Recombinant, Active, Mutant |
| Kinase Assay | |
| 100 μg | |
| aa 27 - end | |
| Recombinant | |
| Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol. | |
| Insect | |
| Liquid |