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Btk (pY551) and Itk (pY511) Mouse, Unlabeled, Clone: 24A/BTK (Y551), BD
Mouse Monoclonal Antibody
Marca: BD Biosciences 558034
380.96 EUR hasta el 2025-12-31
Use el código promocional "25339" para aplicar la oferta.
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Descripción
B ruton's t yrosine k inase (Btk) is a nonreceptor tyrosine kinase whose function is critical for proper B cell development and signaling. The activity of Btk is regulated by Src mediated phosphorylation of the kinase domain at tyrosine 551 (Y551). This event induces Btk kinase activity and subsequent autophosphorylation at Y223. Phosphorylated Btk then associates with the cell membrane via the interaction of the PH domain with phosphatidylinositol 3, 4, 5-triphosphate. γ1 (PLC γ1), a key regulator of calcium mobilization and extracellular signal-regulated kinase (ERK) activation. Itk is regulated by an activating transphosphorylation event in which Y511 in the kinase domain is phosphorylated by Lck.
The 24a/BTK (Y551) monoclonal antibody recognizes the Y551-phosphorylated form of human Btk and the Y511 phosphorylated form of human Itk.
Especificaciones
| Btk (pY551) and Itk (pY511) | |
| Monoclonal | |
| 0.5mg/mL | |
| ATK; BPK; AGMX1 | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Primary | |
| IgG1 κ |
| Western Blot | |
| 24A/BTK (Y551) | |
| Unconjugated | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| Phosphorylated Human Btk Peptide | |
| 0.1 mg | |
| Cell Biology | |
| Store undiluted at 4°C |
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Título del producto
For Research Use Only.
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