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CD127 Rat anti-Mouse, Biotin, Clone: B12-1, BD
Rat Monoclonal Antibody
Marca: BD Biosciences 555288
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Descripción
The B12-1 monoclonal antibody specifically binds to mouse CD127 which is also known as, the Interleukin-7 Receptor alpha chain ( IL-7Rα ). CD127 associates with CD132 ( common γchain ) to form a high-affinity signaling IL-7R complex that mediates the biological effects of IL-7. CD127 can also complex with the Thymic Stromal Lymphopoietin Receptor (TSLPR) subunit to bind and mediate cellular responses to TSLP. CD127 is a 65-75 kDa type-I transmembrane protein that belongs to the hematopoietin receptor and the Ig gene superfamilies. Mice lacking CD127 display profoundly impaired development of the B and T lymphoid cell lineages, but display no obvious non lymphoid abnormalities. IL-7Rα is expressed on common lymphoi with low-density γδ TCR expression upregulate CD127 expression in response to IL-2, which may be secreted by ne ighboring αβ TCR+ T cells.
Especificaciones
| CD127 | |
| Monoclonal | |
| 0.5mg/mL | |
| Interleukin-7 receptor alpha chain; IL-7R alpha; IL7RA;IL-7RA; IL-7Rα; Il7r | |
| Rat | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| Flow Cytometry | |
| B12-1 | |
| Biotin | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| Mouse CD127-human IgG fusion protein | |
| 0.5 mg | |
| Immunology | |
| Mouse | |
| IgG2a λ |
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Título del producto
For Research Use Only.
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