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CD41a Mouse anti-Human, V450, Clone: HIP8, BD
Mouse Monoclonal Antibody
Marca: BD Biosciences 561425
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Descripción
The HIP8 monoclonal antibody specifically binds to the α-chain of CD41. CD41 is also known as Integrin αIIb or Platelet GPIIb. The calcium-dependent complex of CD41 and CD61 (β3 integrin or GPIIIa) is normally expressed on platelets and megakaryocytes. The CD41/CD61 complex is the receptor for fibrinogen, fibronectin and von Willebrand factor, and mediates platelet adhesion and aggregation. CD41 (clone HIP8) completely inhibits ADP-, epinephrine-, and collagen-induced platelet activation, and partially inhibits ristocetin- and thrombin-induced platelet activation. This antibody is useful in the morphological and physiological studies of platelets and megakaryocytes.
Especificaciones
| CD41a | |
| Monoclonal | |
| V450 | |
| Aqueous buffered solution containing protein stabilizer, glycerol and ≤0.09% sodium azide. | |
| Purified platelet membrane glycoproteins | |
| 50 Tests | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| Flow Cytometry | |
| HIP8 | |
| ITGA2B; Integrin alpha-2b (αIIb); Platelet glycoprotein IIb (GPIIb) | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Human | |
| IgG1 κ |