missing translation for 'onlineSavingsMsg'
Learn More
Learn More
Lgr5 (Central LRR) Rat anti-Human, Alexa Fluor 647, Clone: 4D11F8, BD
Rat Monoclonal Antibody
Marca: BD Biosciences 562912
290.47 EUR hasta el 2025-12-31
Use el código promocional "25339" para aplicar la oferta.
Este artículo no se puede devolver.
Vea la política de devoluciones
Descripción
Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5) is a seven transmembrane-domain receptor that is a target gene for Wnt and marks stem cells in the small intestine, colon, stomach, and hair follicle. Lgr5 was initially identified as a potential stem cell marker due to restricted expression of Lgr5 in the intestinal crypt and labeling of rapidly cycling cells of the colon and intestine. Using both lineage tracing and organoid culture experiments, Lgr5 positive cells are capable of generating all types of the small intestine epithelium hence indicating that Lgr5 marks stem cells of the small intestine and colon. R-spondin growth factors, which are secreted agonists of the Wnt pathway, bind Lgr5. The binding of R-spondins to Lgr5 leads to recruitment of the Frizzled/LRP Wnt receptor complex, which binds to Wnt ligands and leads to downstream Wnt signaling. Lgr5 is up-regulated in colon and ovarian cancers and has been implicated in promotion of tumor growth and metastasis.
The 4D11F8 monoclonal antibody recognizes an epitope in the center of the leucine-rich repeat (LRR) region of Human Lgr5.
Host Species: Rat
Clone: 4D11F8
Isotype: IgG2b, λ
Species Reactivity: Hu
Immunogen: Human LGR5 DNA
Flow Cytometry
Especificaciones
| Lgr5 (Central LRR) | |
| Monoclonal | |
| Alexa Fluor 647 | |
| Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide. | |
| Human LGR5 DNA | |
| 50 Tests | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| Flow Cytometry | |
| 4D11F8 | |
| GPR49, GPR67, HG38 | |
| Rat | |
| Affinity Purified | |
| RUO | |
| Human | |
| IgG2b λ |
Corrección del contenido de un producto
Proporcione sus comentarios sobre el contenido del producto rellenando el siguiente formulario.
Título del producto
Lgr5 (Central LRR) Rat anti-Human, Alexa Fluor 647, Clone: 4D11F8, BD > 50 Tests; Alexa Fluor 647
¿Detecta una oportunidad de mejora?Comparta una corrección de contenido
