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LXR beta Monoclonal Antibody (K8917), Invitrogen™
Mouse Monoclonal Antibody
Marca: Invitrogen 418400
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Descripción
This antibody specifically recognizes human LXR beta but does not recognize human LXR alpha. This antibody does not cross react with rat LXR beta. Not yet tested in other species.
The liver X receptors, LXRA and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors and regulate expression of target genes containing LXR response elements.
Especificaciones
| LXR beta | |
| Monoclonal | |
| 1 mg/mL | |
| physiological saline with 0.1% sodium azide | |
| P55055 | |
| NR1H2 | |
| Produced in BALB/c mouse ascites after inoculation with hybridoma of mouse myeloma cells (NS-1) and spleen cells derived from a BALB/c mouse immunized with Baculovirus-expressed recombinant human LXR-beta (2-86 aa). | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG2a |
| ELISA, Immunoprecipitation, Western Blot | |
| K8917 | |
| Unconjugated | |
| NR1H2 | |
| AI194859; liver X nuclear receptor beta; liver X receptor beta; LX receptor beta; LXR; LXR beta; LXRB; LXR-b; LXRbeta; NER; NER1; NER-I; Nr1h2; NR1H2 protein; nuclear orphan receptor LXR-beta; nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; nuclear receptor subfamily 1, group H, member 2; OR-1; Orphan nuclear receptor OR-1; oxysterols receptor LXR-beta; Retinoid X receptor-interacting protein No.15; RIP15; steroid hormone-nuclear receptor NER; ubiquitous receptor; ubiquitously-expressed nuclear receptor; ubiquitously-expressed nuclear receptor 2; UNR; Unr2; UR | |
| Mouse | |
| Ammonium sulfate precipitation | |
| RUO | |
| 7376 | |
| Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C | |
| Liquid |