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PAR4 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marca: Invitrogen PA517408
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Descripción
It is not recommended to aliquot this antibody.
This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases.Especificaciones
PAR4 | |
Polyclonal | |
Unconjugated | |
Pawr | |
2310001G03Rik; coagulation factor II (thrombin) receptor-like 3; Coagulation factor II receptor-like 3; F2R like thrombin/trypsin receptor 3; F2RL3; PAR4; Par-4; par-4 induced by effectors of apoptosis; Pawr; PRKC apoptosis WT1 regulator protein; PRKC, apoptosis, WT1, regulator; pro-apoptotic WT1 regulator; prostate apoptosis response 4; prostate apoptosis response 4 protein; Prostate apoptosis response protein 4; prostate apoptosis response protein PAR-4; prostate apoptosis response-4; protease-activated receptor-4; proteinase-activated receptor 4; Thrombin receptor-like 3; transcriptional repressor PAR4; transcriptional repressor Par-4-like protein PAWR; WT1-interacting protein | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
114774, 5074, 64513 | |
-20°C | |
Liquid |
Flow Cytometry, Immunocytochemistry, Immunoprecipitation, Western Blot | |
65 μg/mL | |
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5 | |
Q62627, Q925B0, Q96IZ0 | |
Pawr | |
Synthetic peptide corresponding to residues surrounding Arg220 of human PAR-4 | |
100 μL | |
Primary | |
Human, Mouse, Non-human Primate, Rat | |
Antibody | |
IgG |