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VCP (Valosin Containing Protein) Mouse, Unlabeled, Clone: 18, BD
Mouse Monoclonal Antibody
343.00€ - 675.00€
Especificaciones
| Antígeno | VCP (Valosin Containing Protein) |
|---|---|
| Clon | 18 |
| Concentración | 250μg/mL |
| Aplicaciones | Western Blot |
| Clasificación | Monoclonal |
| Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
|---|---|---|---|---|---|---|---|---|---|
| Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
|
15876129
|
BD Biosciences
612183 |
150 μg |
675.00€
1 set |
Fecha estimada de envío: 21-08-2024 Inicie sesión para ver el stock |
Por favor, inicie sesión para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo. | ||||
|
15866129
|
BD Biosciences
612182 |
50 μg |
Este artículo actualmente no está disponible o ha sido discontinuado. Ver la página del producto para posibles alternativas |
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Descripción
ATPases that belong to the ATPase associated with different cellular activities (AAA) family are homo-oligomeric proteins that have roles in cell cycle regulation, protein degradation, organelle biogenesis, and vesicle mediated-protein transport. Valosin containing protein (VCP) is a AAA family member that is found as a hexamer in rat liver. In vitro, VCP catalyzes the hydrolysis of ATP, but this activity is distinct from classical transport ATPases. VCP protein is found primarily in the transitional elements between the rough and smooth ER (TER), but stimulation with EGF leads to VCP translocation to the nucleus. Antibodies to VCP can perturb cell-free formation of transition vesicles from isolated TER of rat liver, and can inhibit transfer of material from ER to Golgi in a reconstituted membrane system. VCP is phosphorylated after T-cell activation, and PTPH1 dephosphorylation of VCP correlates with suppression of cell growth. In addition, the N-terminal region of VCP binds to the DNA damage repair protein, BRCA1. Thus, VCP may have roles in both ER protein transport and nuclear function, which are important for cell growth and survival.
Immunofluorescence, Western Blotting
Especificaciones
| VCP (Valosin Containing Protein) | |
| 250μg/mL | |
| Monoclonal | |
| Mouse | |
| Cell Biology | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| IgG1 | |
| Affinity Purified | |
| Valosin Containing Protein |
| 18 | |
| Western Blot | |
| Unconjugated | |
| RUO | |
| Canine, Chicken, Human, Mouse, Rat | |
| Mouse VCP aa. 9-130 | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.