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BMS 536924, Tocris Bioscience™

Catalog Number 30001638
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Cantidad:
10 mg
Este artículo no se puede devolver. Vea la política de devoluciones
468740-43-4
C25H26ClN5O3
479.965
UGQMURPIMYALPH-OAQYLSRUSA-N
s-4-2-3-chlorophenyl-2-hydroxyethyl amino-3-4-methyl-6-morpholino-1h-benzo d imidazol-2-yl pyridin-2 1h-one, 4-2s-2-3-chlorophenyl-2-hydroxyethyl amino-3-4-methyl-6-morpholin-4-yl-3h-1,3-benzodiazol-2-yl-1h-pyridin-2-one
68925359
4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-(4-methyl-6-morpholin-4-yl-1,3-dihydrobenzimidazol-2-ylidene)pyridin-2-one
CC1=CC(=CC2=C1NC(=C3C(=CC=NC3=O)NCC(C4=CC(=CC=C4)Cl)O)N2)N5CCOCC5
Este artículo no se puede devolver. Vea la política de devoluciones
468740-43-4
C25H26ClN5O3
479.965
UGQMURPIMYALPH-OAQYLSRUSA-N
s-4-2-3-chlorophenyl-2-hydroxyethyl amino-3-4-methyl-6-morpholino-1h-benzo d imidazol-2-yl pyridin-2 1h-one, 4-2s-2-3-chlorophenyl-2-hydroxyethyl amino-3-4-methyl-6-morpholin-4-yl-3h-1,3-benzodiazol-2-yl-1h-pyridin-2-one
68925359
4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-(4-methyl-6-morpholin-4-yl-1,3-dihydrobenzimidazol-2-ylidene)pyridin-2-one
CC1=CC(=CC2=C1NC(=C3C(=CC=NC3=O)NCC(C4=CC(=CC=C4)Cl)O)N2)N5CCOCC5

Descripción

Dual IR/IGF1R inhibitor

Dual inhibitor of the insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF1R) (IC50 values are 73 and 100 nM respectively). Inhibits receptor autophosphorylation and downstream MEK1/2 and Akt signaling. Induces G1 arrest and apoptosis in ML-1 cells; also inhibits cell proliferation in multiple tumor types. Reverses EMT through the attenuation of Snail mRNA expression in MCF10A cell over expressing IGF1R.
Nombre del producto químico o material BMS 536924
Cantidad 10 mg
Formula Weight (peso de la fórmula) 479.96
Porcentaje de pureza >98%
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