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Cathepsin F Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Marca: Proteintech 11055-1-AP-150UL
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Descripción
Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W.Especificaciones
Cathepsin F | |
Polyclonal | |
Unconjugated | |
CTSF | |
Cathepsin F, CATSF, CTSF | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
361704, 56464, 8722 | |
-20°C | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot | |
0.25 mg/mL | |
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
Q9R013, Q9UBX1 | |
Ctsf | |
Cathepsin F Fusion Protein Ag1521 | |
150 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |