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Invitrogen™ CCR7 Monoclonal Antibody (4B12)
Rat Monoclonal Antibody
Marca: Invitrogen™ MA1163
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Descripción
MA1-163 has been validated for flow cytometry on primary mouse splenocytes. Optimal staining is observed when incubating the cells with antibody at 37C for at least 30 minutes. MA1-163 has been validated for Western blot on Jurkat cell lysates.
CCR7 is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains and functions as a receptor for 6Ckine/SLC (secondary lymphoid-tissue chemokine), CCL19 and CCL21. CCR7 has been shown to be internalized via clathrin-coated pits and the majority recycled back to the plasma membrane. CCR7 is expressed on T cells and can be used to distinguish populations of naive from central and effector memory T cells. CCR7 has been shown to play a role in migration of memory T cells to inflamed tissue. Expression of CCR7 is also found on DC's. During DC maturation CCR7 expression increases and is thought to be involved in a variety of functions: chemotaxis to the lymph node, cellular architecture, rate of endocytosis, survival and maturation.
Especificaciones
| CCR7 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 1mg/mL BSA, 30% glycerol and 0.05% sodium azide | |
| P32248, P47774 | |
| Ccr7 | |
| Rat basophilic leukaemia (RBL)-2H3 transfectants expressing mouse CCR7. | |
| 100 μg | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG2a |
| Flow Cytometry, Western Blot | |
| 4B12 | |
| Unconjugated | |
| Ccr7 | |
| BLR2; Bukitt's lymphoma receptor 2; CC chemokine receptor 7; C-C chemokine receptor type 7; C-C CKR-7; C-C motif chemokine receptor 7; CC-CKR-7; CCR7; CCR-7; CD197; CDw197; chemokine (C-C motif) receptor 7; chemokine (C-C) receptor 7; Cmkbr7; EBI1; Ebi1h; EBV-induced G protein-coupled receptor 1; EBV-induced G-protein coupled receptor 1; Epstein-Barr virus induced gene 1; Epstein-Barr virus-induced G-protein coupled receptor 1; EVI1; lymphocyte-specific G protein-coupled peptide receptor; MIP-3 beta receptor | |
| Rat | |
| Protein G | |
| RUO | |
| 1236, 12775 | |
| -20°C | |
| Liquid |
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