CD171 Monoclonal Antibody (UJ127), Invitrogen™

Descripción

MA5-14140 targets L1 Cell Adhesion Molecule in immunohistochemistry (paraffin), immunoprecipitation, and Western blot applications and shows reactivity with human samples. The MA5-14140 immunogen is homogenous suspension of 16 week human fetal brain. MA5-14140 has been successfully used in immunohistochemistry analysis of NCAM1 in mouse E16.5 frozen lung sections.

L1CAM/CD171 is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant.