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CD3e Hamster anti-Mouse, APC-Cy7, Clone: 145-2C11, BD
Hamster Monoclonal Antibody
Marca: BD Biosciences 557596
Detalles adicionales : Peso : 0.01000kg
Descripción
The 145-2C11 monoclonal antibody specifically binds to the 25-kDa ε chain of the T-cell receptor-associated CD3 complex that is expressed on thymocytes, mature T lymphocytes, and NK-T cells. The cytoplasmic domain of CD3e participates in the signal transduction events that activate several cellular biochemical pathways as a result of antigen recognition. Soluble 145-2C11 antibody can activate either unprimed (naive) or primed (memory/preactivated) T cells in vivo or in vitro, in the presence of Fc receptor-bearing accessory cells. In contrast, plate-bound 145-2C11 can activate T cells in the absence of accessory cells. Soluble 145-2C11 antibody has been reported to induce re-directed lysis of Fc receptor-bearing target cells by CTL clones and can also block lysis of specific target cells by antigen-specific CTL's. Under some conditions, T-cell activation by 145-2C11 antibody has been reported to result in apoptotic cell death. The 145-2C11 antibody does not cross-react with rat leukocytes. Preincubation of thymus cell suspensions at 37°C for 2-4 hours prior to staining reportedly enhances the ability of anti-CD3ε and anti-αβ TCR mAbs to detect the T-cell receptor on immature thymocytes.
Especificaciones
| CD3e | |
| Monoclonal | |
| 0.2mg/mL | |
| CD3; CD3 epsilon; Cd3e; CD3ε; T3e | |
| Hamster | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| Flow Cytometry | |
| 145-2C11 | |
| APC-Cyanine7 | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| H-2Kb specific cytotoxic T lymphocyte clone BM10-37 | |
| 0.1 mg | |
| Immunology | |
| Mouse | |
| IgG1 κ |
For Research Use Only.