CDK5 Monoclonal Antibody (4E4), Invitrogen™

Descripción

MA5-17053 targets CDK5 in indirect ELISA, FACS, ICC, IHC, IF and WB applications and shows reactivity with Human, Non-human primate, and Rat samples. The MA5-17053 immunogen is purified recombinant fragment of human CDK5 expressed in E. Coli. MA5-17053 detects CDK5 which has a predicted molecular weight of approximately 35kDa.

CDK5 is a member of the Cyclin-Dependent Kinase family that is most abundant in the mammalian brain. Active form of CDK5, which has also been called neuronal cdc2-like kinase, is a heterodimer of CDK5 and a 25 kDa protein which is derived proteolytically from a 35 kDa brain and neuron-specific protein and is essential for the kinase activity of CDK5. CDK5 has emerged as a crucial regulator of neuronal migration in the developing central nervous system. CDK5 phosphorylates a diverse list of substrates, implicating it in the regulation of a range of cellular processes - from adhesion and motility, to synaptic plasticity and drug addiction.