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Chk1 Monoclonal Antibody (6F5), Invitrogen™
Mouse Monoclonal Antibody
Marca: Invitrogen MA123336
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Descripción
MA1-23336 detects Chk1 in Human samples.
CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised. CHK1 is a key mediator in the DNA damage-induced checkpoint network. CHK1 is an evolutionarily conserved protein kinase that functions to ensure genomic integrity upon genotoxic stress. When the G2 or S checkpoint is abrogated by the inhibition of CHK1, p53-deficient cancer cells undergo mitotic catastrophe and eventually apoptosis, whereas normal cells are still arrested in the G1 phase. Thus, CHK1 inhibitors can preferentially potentiate the efficacy of DNA damaging agents in cancer cells, and Chk1 is an attractive therapeutic target for cancer treatment, especially since approximately 50% of all human cancers are p53-deficient.
Especificaciones
| Chk1 | |
| Monoclonal | |
| 3.15 mg/mL | |
| PBS with 20% glycerol and no preservative; pH 7 | |
| O14757, O35280 | |
| Chek1 | |
| Full-length human Chk1 | |
| 100 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG1 |
| Western Blot | |
| 6F5 | |
| Unconjugated | |
| Chek1 | |
| C85740; Cell cycle checkpoint kinase; checkpoint kinase 1; checkpoint kinase 1 homolog; checkpoint kinase-1; Checkpoint, S. pombe, homolog of, 1; CHEK1; CHK1; CHK1 checkpoint homolog; Chk1-S; homolog of Chk1-S; HRD1 Protein; rad27; rad27 homolog; serine/threonine protein kinase CHK1; serine/threonine-protein kinase Chk1; Synoviolin; YBR1742; YBR274W | |
| Mouse | |
| Protein G | |
| RUO | |
| 1111, 12649 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |