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CIP2A Monoclonal Antibody (2G10), Invitrogen™
Mouse Monoclonal Antibody
Marca: Invitrogen MA146001
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Descripción
Suggested positive control: Hela whole cell extract, antigen standard for KIAA1524 (transient overexpression lysate).
Inhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for the transformation of human cells. The protein, designated Cancerous Inhibitor of PP2A (CIP2A), interacts directly with the oncogenic transcription factor c-Myc, inhibits PP2A activity toward c-Myc serine 62 (S62), and thereby prevents c-Myc proteolytic degradation. In addition to its function in c-Myc stabilization, CIP2A promotes anchorage-independent cell growth and in vivo tumor formation. The oncogenic activity of CIP2A is demonstrated by transformation of human cells by overexpression of CIP2A. Importantly, CIP2A is overexpressed in two common human malignancies, head and neck squamous cell carcinoma (HNSCC) and colon cancer.
Especificaciones
| CIP2A | |
| Monoclonal | |
| 1.0 mg/mL | |
| tris glycine with 0.15M NaCl and 0.05% sodium azide | |
| Q8BWY9, Q8TCG1 | |
| Cip2a | |
| A C-terminal portion of the human p90 protein. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Non-human Primate, Rat | |
| Antibody | |
| IgG2b κ |
| Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot | |
| 2G10 | |
| Unconjugated | |
| Cip2a | |
| AA408511; AU018569; C330027C09Rik; Cancerous inhibitor of PP2A; cancerous inhibitor of protein phosphatase 2A; Cip2a; Kiaa1524; p90; p90 autoantigen; p90 autoantigen homolog; Protein CIP2A; RGD1310335; RIKEN cDNA C330027C09 gene; similar to RIKEN cDNA C330027C09 | |
| Mouse | |
| Protein G | |
| RUO | |
| 224171, 360711, 57650 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |