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Connexin 46 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marca: Invitrogen 388300
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Descripción
38-8300 detects Cx46 in IHC application in cryostat sections of adult mouse lens.
Connexin 46 (Cx46), also known as Gap Junction Protein Alpha-3 (GJA3), CAE3, CX46 and C2P3, maps to human chromosome 13q11-q12 and encodes a 46 kDa protein. Cx46, along with Cx50, is principally expressed in the lens of the eye. Cx46 mediates intercellular interactions during development and is necessary for the survival of neural crest cells. Cx46 forms gap junctions that connect lens fiber cells and are crucial for maintaining lens transparency and normal lens function. Mutations of Cx46 result in severe cataracts of the lens. Individual knockouts of Cx46 and Cx50 lead to changes in the rate of lens fiber cell differentiation and cell size, thus the interaction of Cx46 and Cx50 is required for proper organization of fiber cells.
Especificaciones
| Connexin 46 | |
| Polyclonal | |
| Unconjugated | |
| GJA3 | |
| alpha 3 connexin; Cnx46; connexin 46; connexin-46; CTRCT14; Cx43; CX46; Cxn-46; CZP3; gap junction alpha 3; gap junction alpha-3 protein; gap junction membrane channel protein alpha 3; gap junction protein alpha 3; gap junction protein, alpha 3; gap junction protein, alpha 3, 46kDa; Gja3; Gja-3 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 14611 | |
| -20°C | |
| Liquid |
| Immunocytochemistry, Immunohistochemistry (Frozen), Western Blot | |
| 0.25 mg/mL | |
| PBS with 0.1% sodium azide; pH 7.4 | |
| Q64448 | |
| GJA3 | |
| Synthetic peptide derived from an internal region of the mouse Connexin 46 protein | |
| 100 μg | |
| Primary | |
| Mouse | |
| Antibody | |
| IgG |