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Tocris Bioscience™ CST 905
Potent and selective BRAFV600E Degrader (PROTAC™)
Marca: Tocris Bioscience™ 7745/5
Detalles adicionales : Peso : 0.00970kg
Descripción
CST 905 is a potent and selective BRAFV600E Degrader (PROTAC™) (DC50 = 18 nM). CST 905 comprises a ligand for the von Hippel Lindau (VHL) E3 ligase joined by a linker to a PLX-derived ligand. Unlike other BRAFV600E Degraders, CST 905 does not activate ERK. B-Raf antibody validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF3424 . PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.Especificaciones
| (2S,4R)-1-((S)-2-(2-(4-(4-(3-(3-((N-Ethyl-N-methylsulfamoyl)amino)-2,6-difluorobenzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide | |
| Active Degraders | |
| 98% |
| 5 mg | |
| C51H58F2N10O7S2 |