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DR4 Monoclonal Antibody (32A242), Invitrogen™
Mouse Monoclonal Antibody
Marca: Invitrogen MA141049
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Descripción
Suggested positive control: Hela whole cell extract, HeLa cell lysate.
TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues. Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor).
Especificaciones
| DR4 | |
| Monoclonal | |
| 1.0 mg/mL | |
| PBS with 0.05% sodium azide | |
| O00220 | |
| TNFRSF10A | |
| Synthetic peptide corresponding to residues 2-21 of mature human DR4. | |
| 100 μg | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG1 |
| Immunocytochemistry, Western Blot | |
| 32A242 | |
| Unconjugated | |
| TNFRSF10A | |
| APO2; CD261; cytotoxic TRAIL receptor; death receptor 4; DR4; MGC9365; sCD261; soluble CD261; soluble TRAIL; sTRAIL; TNF receptor superfamily member 10a; TNF-related apoptosis-inducing ligand receptor 1; TNFRSF10A; TRAIL R1; TRAIL receptor 1; TRAILR1; TRAIL-R1; TRAILR-1; tumor necrosis factor receptor superfamily member 10A; tumor necrosis factor receptor superfamily member 10a variant 2; tumor necrosis factor receptor superfamily, member 10a | |
| Mouse | |
| Protein G | |
| RUO | |
| 8797 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
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