ERBB2 Mouse anti-Human, Mouse, Rat, Clone: UMAB36, liquid, UltraMAB™

ErbB2 (Her2/neu) is a 185 kDa transmembrane receptor tyrosine kinase from the EGFR (epidermal growth factor receptor) family that regulates biological responses such as cell growth, differentiation, and tissue development. ErbB2 has no ligand binding domain of its own and cannot bind growth factors. However, ErbB2 does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signaling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Autophosphorylation of tyrosine 1139 on ErbB2 allows binding of Grb2 and the Src SH2 domain, which allows activation of the Ras, Raf, ERK1/2 and JAK/STAT signaling pathways, respectively. Alternative splicing of ErbB2 results in several transcript variants, some encoding different isoforms and others that have not been fully characterized. In humans, the gene encoding ERBB2 is present on chromosome 17. Amplification and/or overexpression of the ErbB2 gene has been reported in ovarian tumors, breast, lung and skin cancer.