Fascin Monoclonal Antibody (FCN01 (55K-2)), Invitrogen™

Descripción

MA5-11483 targets Fascin in IHC (P) applications and shows reactivity with Human and Rat samples. The MA5-11483 immunogen is fascin purified from HeLa cells.

Human fascin is a highly conserved actin-bundling protein. Fascin, encoded by the human homolog for sn (hsn) gene, has been localized to microspikes and stress fibers of cultured cells where it is thought to be involved in the formation of microfilament bundles. It is expressed predomitly in dendritic cells. Lymphoid cells, myeloid cells and plasma cells are negative. However. Reed Sternberg cells in Hodgkin′s lymphoma are positive for fascin staining. Epstein-Barr virus may induce expression of fascin in B cells.