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Invitrogen™ FNIP2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Marca: Invitrogen™ PA520690
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Descripción
A suggested positive control is rat skeletal muscle tissue lysate. PA5-20690 can be used with blocking peptide PEP-0805.
FNIP2 is the second protein found to interact with folliculin, the product of the Birt-Hogg-Dube (BHD) gene. Folliculin is thought to act as a tumor suppressor as mutations or loss of heterozygosity in this gene are associated with BHD syndrome-related renal tumors. Folliculin and FNIP1, a protein that shares 49% identity to FNIP2, bind to AMPK, an important energy sensor in cells that negatively regulates the mammalian target of rapamycin (mTOR), a protein that is thought to be the master switch for cell growth and proliferation. FNIP1 and FNIP2 are able to form homo- and heteromeric multimers, suggesting these proteins may have a functional relationship.
Especificaciones
| FNIP2 | |
| Polyclonal | |
| Unconjugated | |
| FNIP2 | |
| D630023B12Rik; FNIP1-like protein; Fnip2; Fnipl; folliculin interacting protein 2; folliculin-interacting protein 2; KIAA1450; MAPO1; mKIAA1450; O6-methylguanine-induced apoptosis 1 protein; RGD1562174 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 310538, 329679, 57600 | |
| Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C | |
| Liquid |
| Immunohistochemistry, Western Blot | |
| 1 mg/mL | |
| PBS with 0.02% sodium azide | |
| Q80TD3, Q9P278 | |
| FNIP2 | |
| A 16 amino acid peptide near the carboxy terminus of human FNIP2. | |
| 100 μg | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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