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Thermo Scientific™ GeneBLAzer™ M4-Gqo5-NFAT-bla CHO-K1 Cells
GeneBLAzer™ M4 Gqo5-NFAT-bla CHO-K1 cells contain the human Acetylcholine (muscarinic) subtype 4 receptor (M4) stably integrated into the GeneBLAzer™ Gqo5-NFAT-bla CHO-K1 cell line.
Marca: Thermo Scientific™ K1741
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Descripción
GeneBLAzer™ M4 Gqo5-NFAT-bla CHO-K1 cells contain the human Acetylcholine (muscarinic) subtype 4 receptor (M4) stably integrated into the GeneBLAzer™ Gqo5-NFAT-bla CHO-K1 cell line. GeneBLAzer™ Gqo5-NFAT-bla CHO-K1 cells (Cat. No. K1536) contain a beta-lactamase reporter gene under control of the Nuclear Factor of Activated T-cells (NFAT) response element and the Chimeric G protein, Gqo5.
The GeneBLAzer™ M4 Gqo5-NFAT-bla CHO-K1 cells are functionally validated for Z' and EC50 concentrations of Cabachol. In addition, GeneBLAzer™ M4 Gqo5-NFAT-bla CHO-K1 cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.
The clinical implications of the M4 receptor are unknown, however studies with knockout mice suggest that M4 may have implications in dopaminergic function, karatinocyte migration and wound healing, anxiolysis, and analgesia. In addition, M4 may be important in memory circuits and have implications in Alzheimer's Disease. Additional information on the muscarinic receptors can be found in literature.
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Especificaciones
| NM_000741 | |
| Células divisoras | |
| Estado de la población: Origen del clon unicelular | |
| FRET | |
| Células M4 Gqo5 CHO-K1 DA GeneBLAzer™, protocolo de ensayo M4 Gqo5 CHO-K1 DA GeneBLAzer™, certificado de análisis, solución D, protocolo de carga LiveBLAzer™-FRET B⁄G | |
| GeneBLAzer™ | |
| BLA (betalactamasa) | |
| Células en proceso de división | |
| GeneBLAzer™ |
| Gen informador de beta lactamasa a base de células | |
| Contenido: Células K1741 GeneBLAzer™ M4 Gqo5 CHO-K1 DA (El kit de carga LiveBLAzer™-FRET B⁄G, la solución D y otros materiales se solicitan por separado; consulte el protocolo). Incluye: • Células GeneBLAzer™ M4 Gqo5 CHO-K1 DA • Protocolo de ensayo GeneBLAzer™ M4 Gqo5 CHO-K1 DA • Certificado de análisis • Solución D • Protocolo de carga LiveBLAzer™-FRET B⁄G Almacenamiento: Las células GeneBLAzer™ M4-Gqo5-NFAT-bla CHO-K1 se envían con hielo seco y deben almacenarse en nitrógeno líquido inmediatamente después de su recepción. |
|
| Fluorescente | |
| M4 | |
| Origen del clon unicelular | |
| 2 x 106 células | |
| M4 | |
| CHO-K1 | |
| GPCR |
Para uso exclusivo en investigación. No apto para uso en procedimientos diagnósticos.