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GRB2 Monoclonal Antibody (2GB04 (C1.4)), Invitrogen™
Mouse Monoclonal Antibody
Marca: Invitrogen AHO0522
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Descripción
This antibody reacts with an epitope at aa 54-62. Staining of formalin-fixed paraffin-embedded tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 20 min followed by cooling at room temperature for 20 min. Recommended positive controls include HeLa cells and tonsil tissue.
GRB 2 protein contains one SH2 domain flanked on both sides by an SH3 domain. In response to EGF, GRB 2 binds, through its SH3 domains, to the guanine nucleotide exchange factor, Sos. The GRB 2 - Sos complex then binds the EGF receptor. These interactions play a critical role in the activation of the p21 ras signalling pathway.
Especificaciones
| GRB2 | |
| Monoclonal | |
| 0.2 mg/mL | |
| GRB2 | |
| ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2, HT027, SH2/SH3 adapter GRB2, abundant SRC homology, epidermal growth factor receptor-binding protein GRB2, growth factor receptor-bound protein 3, protein Ash | |
| Mouse | |
| Protein G | |
| RUO | |
| 14784, 2885, 535298, 81504 | |
| 4° C | |
| Liquid |
| Immunofluorescence, Immunohistochemistry (Paraffin) | |
| 2GB04 (C1.4) | |
| Unconjugated | |
| P62993, Q60631, P62994 | |
| GRB2 | |
| Purified recombit human Grb2 protein. | |
| 500 μL | |
| Primary | |
| Bovine, Human, Mouse, Rat, X. laevis | |
| Antibody | |
| IgG1 κ |
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