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HIF3A Monoclonal Antibody (OTI5B7), TrueMAB™, OriGene
Mouse Monoclonal Antibody
Marca: Origene Technologies TA800761
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Descripción
Cell growth and viability is compromised by oxygen deprivation (hypoxia). Hypoxia-inducible factors, including HIF-1 alpha, HIF-1 beta (also designated Arnt 1), EPAS-1 (also designated HIF-2 alpha) and HIF-3 alpha, induce glycolysis, erythropoiesis and angiogenesis in order to restore oxygen homeostasis. Hypoxia-inducible factors are members of the Per-Arnt-Sim (PAS) domain transcription factor family. In response to hypoxia, HIF-1 alpha is upregulated and forms a heterodimer with Arnt 1 to form the HIF-1 complex. The HIF-1 complex recognizes and binds to the hypoxia responsive element (HRE) of hypoxia-inducible genes, thereby activating transcription.Especificaciones
| HIF3A | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
| Q9Y2N7 | |
| HIF3A | |
| Human recombit protein fragment corresponding to amino acids 355-669 of human HIF3A produced in E.coli. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| Western Blot | |
| OTI5B7 | |
| Unconjugated | |
| HIF3A | |
| HIF-3A, HIF3-alpha-1, IPAS, MOP7, PASD7, bHLHe17 | |
| Mouse | |
| Affinity Chromatography | |
| RUO | |
| 64344 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
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