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Cytiva™ HiScreen™ Column with MabSelect™ VL Protein L Resin
These HiScreen™ columns contain Protein L resin for affinity capture of antibody Fabs, bispecifics, and other variants containing a kappa light chain.
Marca: Cytiva™ 17542015
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Descripción
As the diversity of antibody variants increases, so does the need for chromatography resins that can capture and purify these variants. As an alternative to protein A, protein L resin can be used to capture antibody Fabs, bispecific antibodies, and other molecules containing kappa variants of the variable light (VL) chain. Protein L binds human kappa light chain subtypes 1, 3, and 4 and mouse kappa light chain subtype 1.
Redesigned protein L ligand MabSelect™ VL protein L resin showed a two-fold increase in binding capacity compared to Cytiva™ Capto™ L chromatography resin. This higher capacity provides productivity advantages in research and biomanufacturing.
- A redesigned protein L ligand captures antibody Fabs, bispecifics, and other variants containing a kappa light chain with high binding capacity and improved alkaline stability
- High dynamic binding capacity for efficient capture of target molecules
- Stable when cleaned with 0.1 M NaOH, reducing risk for bioburden incidents
- Provides good resolution for product-related impurities in the capture of bispecific antibodies
- Convenient for method optimization and parameter screening enabled by the 10 cm bed height for efficient chromatography process development
Especificaciones
| 70 mg Human IgG/mL Resin at 6 min. Residence Time, 60 mg Human IgG/mL Resin at 4 min. Residence Time | |
| 0.3 in. | |
| <300 cm/hr. | |
| 60 μm | |
| 1 Column | |
| Antibody | |
| Chromatography Column | |
| Affinity |
| 4.7 mL | |
| 7.7 mm | |
| 3 bar | |
| HiScreen™ MabSelect™ | |
| Antibody Affinity Chromatography | |
| Pre-packed Column | |
| 100 mm |