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Gibco™ Human IGF-BP3, Animal-Free Recombinant Protein, PeproTech®

Código de producto. 17886568
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Cantidad:
250 μg
5 μg
Tamaño de la unidad:
250 microgramos
5 microgramos
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Código de producto. 17886568

Marca: Gibco™ AF10008250UG

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Descripción

Recombinant Protein

Recombinant Human IGF-BP3 is a 28.8 kDa protein consisting of 264 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

IGFBP3 is a gene that belongs to the insulin-like growth factor binding protein (IGFBP) family. The gene encodes a protein that contains both an IGFBP domain and a thyroglobulin type-I domain. This protein is known to form a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. The complex circulates in the plasma and prolongs the half-life of IGFs while also altering their interaction with cell surface receptors. Various isoforms of the gene have been identified through alternate transcriptional splice variants. Diseases associated with IGFBP3 include Insulin-Like Growth Factor I and Acid-Labile Subunit Deficiency.
TRUSTED_SUSTAINABILITY

Specifications

Número de acceso P17936
Para utilizar con (aplicación) Functional Assay
Formato Lyophilized
Formulación protein with no preservative
ID de gen (Entrez) 3486
Peso molecular 28.8 kDa
Nombre Human IGF-BP3, Animal-Free
Método de purificación HPLC, SDS-PAGE
Cantidad 250 μg
Estado normativo RUO
Concentración de endotoxinas <0.1 EU/ μg
Alias de gen acid stable subunit of the 140 K IGF complex; AI649005; binding protein 29; binding protein 53; BP53; BP-53; Growth hormone dependent binding protein; growth hormone-dependent binding protein; I79_011450; IBP3; IBP-3; IGF binding protein 3; IGF-binding protein 3; IGFBP; Igfbp3; IGF-BP3; IGFBP-3; IGgfbp3; Insulin like growth factor binding protein; insulin like growth factor binding protein 3; insulin-like growth factor binding protein 3; Insulin-like growth factor binding protein 3 precursor; insulin-like growth factor-binding protein (IGF-BP3); insulin-like growth factor-binding protein 3; tcag7.703
Nombre común IGFBP3
Símbolo de gen IGFBP3
Actividad biológica Determined by its ability to inhibit IGF-II induced proliferation of MCF-7. The expected ED50 is ≤ 0.2 ug/ml in the presence of 15 ng/ml of human IGF-II.
Tipo de producto Protein
Conjugado Unconjugated
Recombinante Recombinant
Secuencia GASSGGLGPV VRCEPCDARA LAQCAPPPAV CAELVREPGC GCCLTCALSE GQPCGIYTER CGSGLRCQPS PDEARPLQAL LDGRGLCVNA SAVSRLRAYL LPAPPAPGNA SESEEDRSAG EVESPSVSST HRVSDPKFHP LHSKIIIIKK GHAKDSQRYK VDYESQSTDT QNFSSESKRE TEYGPCRREM EDTLNHLKFL NVLSPRGVHI PNCDKKGFYK KKQCRPSKGR KRGFCWCVDK YGQPLPGYTT KGKEDVHCYS MQSK
Contenido y almacenamiento -20°C
Actividad Determined by its ability to inhibit IGF-II induced proliferation of MCF-7. The expected ED50 is ≤ 0.2 ug/ml in the presence of 15 ng/ml of human IGF-II.
Sistema de expresión E. coli
Formulario Lyophilized
Grado de pureza o calidad ≥ 98% by SDS-PAGE gel and HPLC analyses.
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