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ACROBiosystems Human IL-15 Protein, His Tag
MALS verified
Marca: ACROBiosystems IL5-H52H8-1mg
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Descripción
Interleukin 15 is also known as IL15, IL-15, and is a cytokine with structural similarity to IL-2. Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells. Interleukin 15 (IL-15) regulates T and natural killer (NK) cell activation and proliferation. Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15. This cytokine is also implicated in NK cell development. In rodent lymphocytes, IL-15 prevents apoptosis by inducing an apoptosis inhibitor, BCL2L1/BCL-x(L). IL-15 has been shown to enhance the anti-tumor immunity of CD8+ T cells in pre-clinical models. A phase I clinical trial to evaluate the safety, dosing, and anti-tumor efficacy of IL-15 in patients with metastatic melanoma and renal cell carcinoma (kidney cancer) has begun to enroll patients at the National Institutes of Health.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 14.8 kDa. The protein migrates as 17-25 kDa under reducing (R) condition (SDS-PAGE) due to Glycosylation.Especificaciones
| 14.8 kDa | |
| Human IL-15, His Tag (IL5-H52H8) is expressed from human 293 cells (HEK293). It contains AA Asn 49 - Ser 162 (Accession # P40933-1). | |
| -20°C | |
| IL-15 | |
| Human | |
| PBS, pH7.4 | |
| HEK293 | |
| Cytokines and Growth Factors |
| 1 mg | |
| Asn 49 - Ser 162 | |
| IL-15,Interleukin-15,MGC9721 | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >90% as determined by SDS-PAGE |