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ACROBiosystems Human IL-23 alpha&IL-12 beta Heterodimer Protein, His Tag&Tag Free
Marca: ACROBiosystems ILB-H52W5-50UG
Detalles adicionales : Peso : 0.00001kg
Descripción
Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Human IL-23A&IL-12B Heterodimer Protein, His Tag&Tag Free, produced by co-expression of IL-23 alpha and IL-12 beta, has a calculated MW of 19.5 kDa (IL-23 alpha) and 34.7 kDa (IL-12 beta). Subunit IL-23 alpha is fused with a polyhistidine tag at the N-terEspecificaciones
NP_057668.1 (IL23A) and NP_002178.2 (IL12B) | |
50 μg | |
Arg 20 - Pro 189 (IL23A) and Ile 23 - Ser 328 (IL12B) | |
IL-23 alpha and IL-12 beta | |
Unconjugated | |
His Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>95% as determined by SDS-PAGE |
19.5 kDa (IL23A) and 34.7 kDa (IL12B) | |
Human IL-23 A&IL-12; B Heterodimer Protein, His Tag&Tag; Free (ILB-H52W5) is expressed from human 293 cells (HEK293). It contains AA Arg 20 - Pro 189 (IL23A) and Ile 23 - Ser 328 (IL12B) (Accession # Q9NPF7-1 (IL23A) and P29460-1 (IL12B)). | |
-20°C | |
IL23A and IL12B | |
Human | |
PBS, pH7.4 | |
HEK293 | |
Cytokines and Growth Factors |