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Gibco™ Human Klotho Recombinant Protein, PeproTech®
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Cantidad:
100 μg
2 x 500 μg
20 μg
250 μg
500 μg
5 μg
Tamaño de la unidad:
1 miligramo
100 microgramos
20 microgramos
250 microgramos
5 microgramos
500 microgramos
paquete de 2
Descripción
100-53-1MG will be provided as 2 x 500 μg (100-53-500UG). Recombinant Human Klotho is a glycoprotein of 516 amino acid residues that migrates at an apparent molecular weight of 65-70 kDa by SDS-PAGE analysis under reducing conditions. Recombinant Human Klotho has a calculated molecular weight of 58.6 kDa. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.
Especificaciones
Especificaciones
| Número de acceso | Q9UEF7 |
| Para utilizar con (aplicación) | ELISA, Functional Assay, Western Blot |
| Formulación | protein with no preservative |
| ID de gen (Entrez) | 9365 |
| Peso molecular | 58.6 |
| Nombre | Human Klotho |
| Cantidad | 2 x 500 μg |
| Fuente | CHO cells |
| Requisitos de almacenamiento | -20°C |
| Estado normativo | RUO |
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