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Gibco™ Human TNF-alpha Recombinant Protein, PeproTech®
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Cantidad:
100 μg
10 μg
1 mg
250 μg
500 μg
50 μg
Tamaño de la unidad:
1 miligramo
10 microgramos
100 microgramos
250 microgramos
50 microgramos
500 microgramos
Descripción
Recombinant Human TNF-alpha is a soluble 157 amino acid protein (17.4 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
Especificaciones
Especificaciones
| Número de acceso | P01375 |
| Para utilizar con (aplicación) | ELISA, Functional Assay, Western Blot |
| Formulación | protein with no preservative |
| ID de gen (Entrez) | 7124 |
| Peso molecular | 17.4 kDa |
| Nombre | Human TNF-alpha |
| Cantidad | 100 μg |
| Fuente | E. coli |
| Estado normativo | RUO |
| Concentración de endotoxinas | <1 EU/ μg |
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