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Tocris Bioscience™ JNJ 1013
Interleukin 1 Receptor Associated Kinase 1 (IRAK1) PROTAC™
Marca: Tocris Bioscience™ 8029/5
Detalles adicionales : Peso : 0.00970kg
Descripción
JNJ 1013 is a potent interleukin 1 receptor associated kinase 1 (IRAK1) PROTAC™ Degrader (DC50 = 3 nM; Dmax = 96%). In ABC DLBCL cell lines with MyD88 L265P mutation, JNJ 1013 potently inhibits IRAK1 downstream signaling pathways, induces apoptosis, and shows strong anti-proliferative effects. PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.Especificaciones
| N-(4-(4-(2-(((S)-1-((2S,4R)-4-Hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethoxy)piperidin-1-yl)-2-methoxyphenyl)-6-(1H-pyrazol-5-yl)picolinamide | |
| 5 mg | |
| C46H55N9O7S |
| 2597343-08-1 | |
| Active Degraders | |
| 98% |