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ACROBiosystems Mouse TIM-3 / HAVCR2 Protein, His Tag
423.38€ - 2201.57€
Especificaciones
Peso molecular | 21.0 kDa |
---|---|
Fuente | Mouse TIM-3, His Tag (TI3-M52H1) is expressed from human 293 cells (HEK293). It contains AA Arg 20 - Arg 191 (Accession # AAL65156.1). |
Inmunógeno | Arg 20 - Arg 191 |
Requisitos de almacenamiento | -20°C |
Alias de gen | HAVCR2,TIM3,TIMD3,FLJ14428,KIM3 |
Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
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Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
15887767
|
ACROBiosystems
TI3-M52H1-100UG |
100 μg |
423.38€
100 microgramos |
Fecha estimada de envío: 07-08-2024 Inicie sesión para ver el stock |
Por favor, inicie sesión para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo. | ||||
15897767
|
ACROBiosystems
TI3-M52H1-1MG |
1 mg |
2201.57€
1 miligramo |
Fecha estimada de envío: 07-08-2024 Inicie sesión para ver el stock |
Por favor, inicie sesión para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo. | ||||
Descripción
Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 21.0 kDa. The protein migrates as 33-47 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Especificaciones
21.0 kDa | |
Arg 20 - Arg 191 | |
HAVCR2,TIM3,TIMD3,FLJ14428,KIM3 | |
Unconjugated | |
His Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>95% as determined by SDS-PAGE |
Mouse TIM-3, His Tag (TI3-M52H1) is expressed from human 293 cells (HEK293). It contains AA Arg 20 - Arg 191 (Accession # AAL65156.1). | |
-20°C | |
TIM-3 | |
Mouse | |
PBS, pH7.4 | |
HEK293 | |
Immune Checkpoint Proteins |