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NMDAR2B Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marca: Invitrogen PA34665
Detalles adicionales : Peso : 0.01000kg
Descripción
This antibody is specific for the ∽180 kDa NR2B subunit of the NMDA Receptor. There is no reactivity towards the NR2A and NR2C subunits. Immunolabeling is blocked by preadsorption of antibody with the fusion protein used to generate the antibody.
NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. NMDA receptors (NMDAR) have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDAR play a role in neuronal development and has been implicated in several disorders of the central nervous system including Alzheimer’s Disease, epilepsy and ischemic neuronal cell death. Overexpression of the NR2B subunit of the receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression. Tyr1472 on NR2B is phosphorylated and this may lead to the increased expression of the NMDAR at the synapse that plays a role in synaptic plasticity. NMDR2B is a heterotrimer comprised of seven enetically encoded and differentially expressed subunits that include NR1, NR2 and NR3. Diseases associated with the dysfunction of NMDAR2B include epileptic encephalopathy, autosomal dominant 6-related mental retardation.Especificaciones
NMDAR2B | |
Polyclonal | |
Unconjugated | |
GRIN2B | |
AW490526; EIEE27; GluN2B; GluRepsilon2; glutamate [NMDA] receptor subunit epsilon-2; glutamate ionotropic receptor NMDA type subunit 2B; glutamate receptor; glutamate receptor ionotropic, NMDA 2B; glutamate receptor subunit epsilon-2; glutamate receptor, ionotropic, NMDA2B; glutamate receptor, ionotropic, NMDA2B (epsilon 2); glutamate receptor, ionotropic, N-methyl D-aspartate 2B; GRIN 2B; GRIN2B; HGNC:4586; hNR 3; hNR3; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2B; MGC142178; MGC142180; MRD6; Nmdar2b; NMDE2; NME2; N-methyl D-aspartate receptor 2B; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 2B; N-methyl-D-aspartate receptor subunit 3; NR2B; NR3 | |
Rabbit | |
50 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
Immunocytochemistry, Western Blot | |
Conc. Not Determined | |
whole serum with no preservative | |
Q00960, Q01097, Q13224 | |
GRIN2B | |
Fusion protein from the C-terminal region of the NR2B subunit of rat GRIN2B | |
RUO | |
14812, 24410, 2904 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Liquid |