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NOSIP Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marca: Invitrogen PA522206
Detalles adicionales : Peso : 0.01000kg
Descripción
Recommended positive controls: A431, H1299. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
NEDD4L is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. NEDD4L inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. NEDD4L promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1. 2, Nav1. 3, Nav1. 5, Nav1. 7, Nav1. 8, Kv1. 3, EAAT1 or CLC5. NEDD4L also promotes ubiquitination and degradation of SGK.Especificaciones
| NOSIP | |
| Polyclonal | |
| Unconjugated | |
| NOSIP | |
| 2310061K06Rik; CGI-25; E3 ubiquitin-protein ligase NOSIP; eNOS-interacting protein; nitric oxide synthase interacting protein; nitric oxide synthase-interacting protein; Nosip; RING-type E3 ubiquitin transferase NOSIP | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 51070 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Western Blot | |
| 0.99 mg/mL | |
| 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7 | |
| Q9Y314 | |
| NOSIP | |
| Synthetic peptide corresponding to a region within amino acids 90 and 184 of NOSIP (Uniprot ID#Q9Y314) | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |