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Descripción
This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.
General Description
• Novobiocin sodium salt, first isolated from Streptomyces nieveus, is a topoisomerase II inhibitor. It is a coumarin compound showing antibiotic activity
• Novobiocin sodium salt can inhibit DNA synthesis by inhibiting the topoisomerase II enzyme. Its antibacterial activity arises from competitive inhibition of the ATPase reaction catalyzed by the GyrB subunit
Application
• Novobiocin sodium salt is used to inhibit the activity of retroviral RNA-dependent DNA polymerase in laboratory experiments
• It is also used as an inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase.
• Novobiocin sodium salt shows anti-staphylococcal activity against methicillin-resistant Staphylococcus aureus, a gram-positive bacterium
• It permits the relaxation of negative DNA supercoils and has been used to generate positively supercoiled DNA
• This compound inhibits the chaperone activity of Hsp90

Certificados
Certificados
Se requiere un número de lote para mostrar resultados para certificados. Para encontrar su número de lote en pedidos anteriores, utilice el área de estado de pedidos.
Número de lote | Tipo de certificado | Fecha | Catalog Number |
---|---|---|---|
Z24K043 | Certificado de análisis | 21/01/2025 | J60928.03,J60928.06,J60928.09 |
W19K020 | Certificado de análisis | 27/09/2024 | J60928.03,J60928.06,J60928.09 |
Q23K037 | Certificado de análisis | 11/06/2024 | J60928.03,J60928.06,J60928.09 |
Q05K033 | Certificado de análisis | 18/04/2024 | J60928.03,J60928.06,J60928.09 |
P02K007 | Certificado de análisis | 25/03/2024 | J60928.03,J60928.06,J60928.09 |
RUO – Research Use Only
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