O-linked N-acetylglucosamine (O-GlcNAc) Monoclonal Antibody (9D1.E4), Invitrogen™

Descripción

MA1-039 has been successfully used in Western blot and immunoprecipitation applications with human samples. In Western blot, MA1-039 detects proteins with O-GlcNAc post-translational modification, and therefore will detect multiple specific bands.

O-linked N-acetylglucosamine (O-GlcNAc) is a posttranslational modification characterized by the attachment of N-acetylglucosamine to specific serine or threonine residues. Unlike other protein glycosylations, O-GlcNAc modifications occur within the nucleus and cytoplasm. They are found on many cellular proteins, including nuclear pore, oncogene, cytoskeletal, heat shock, viral and transcription regulatory proteins. O-GlcNAc glycosylations are thought to obscure phosphorylation sites, counteracting phosphorylation-dependent signaling pathways and protein interactions.