OPRL1 Polyclonal Antibody, Invitrogen™

Descripción

IHC (P) analysis shows positive staining of NOP in human enteric ganglion. WB analysis shows NOP in glycoprotein-enriched fractions from mock transfected or NOP overexpressing 293 cells. While NOP has a theoretical MW of ∽ 41kD, the observed band in a WB runs at ∽72kD due to enrichment of the glycosylated receptor.

The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. The nociceptin receptor is a G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.