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p21 Monoclonal Antibody (GT8611), Invitrogen™
Mouse Monoclonal Antibody
Marca: Invitrogen MA531480
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Descripción
Keep as concentrated solution. Predicted reactivity: Cat (84%), Sheep (82%), Rhesus Monkey (98%), Bovine (83%). Positive Control: HeLa, HCT116 (30 μM Cisplatin treatment for 24 hr). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Protein p21 is a tumor suppressor protein which is an inhibitor of Cyclin-dependent kinases (CDK) and is transcriptionally activated by p53. P21 is important in the response of cells to genotoxic stress and a major transcriptional target of p53 protein. The occurrence of p21 in the nucleus executes binding and inhibition activity of cyclin dependent kinases Cdk1 and Cdk2, and blocks the transition from G1 phase into S phase or from G2 phase into mitosis after DNA damage, which enables the repair of damaged DNA. In the cytoplasm, p21 protein has an anti-apoptotic effect. P21 is able to bind to and inhibit caspase 3, as well as the apoptotic kinases ASK1 and JNK. P21 exhibits a dual function in carcinogenesis, and acts as a tumor suppressor, prevents apoptosis, and acts as an oncogene.
Especificaciones
| p21 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with no preservative | |
| P38936 | |
| CDKN1A | |
| Recombinant protein encompassing a sequence within the center region of human p21 Cip1. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG2b |
| Flow Cytometry, Immunocytochemistry, Western Blot | |
| GT8611 | |
| Unconjugated | |
| CDKN1A | |
| Activating Fragment 1; CAP20; cdk inhibitor CIP1; cdk inhibitor CIP1 (p21); CDKI; CDK-interacting protein 1; CDK-interaction protein 1; Cdkn1; CDKN1A; CDNK1A; CIP1; Cip1); cyclin dependent kinase inhibitor 1A; cyclin-dependent kinase inhibitor 1; cyclin-dependent kinase inhibitor 1A; Cyclin-dependent kinase inhibitor 1A (p21; cyclin-dependent kinase inhibitor 1A (P21); cyclin-dependent kinase inhibitor 1A (p21, Cip1); cyclin-dependent kinase inhibitor 1A variant 1; cyclin-dependent kinase inhibitor 1A variant 2; DNA synthesis inhibitor; MDA6; MDA-6; melanoma differentiation associated protein 6; melanoma differentiation-associated protein; Melanoma differentiation-associated protein 6; OTTHUMP00000016298; p21; p21<WAF1/CIP1>; p21Cip1; p21Cip1/Waf1; p21WAF; PIC1; putative cyclin-dependent kinase inhibitor 1A (p21/WAF1/CIP1); SDI1; SLC12A9; UV96; WAF1; Wild type p53 activated fragment 1 (WAF1); wild-type p53-activated fragment 1 | |
| Mouse | |
| Protein G | |
| RUO | |
| 1026 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |