p38 MAPK beta Polyclonal Antibody, Invitrogen™

Descripción

Recommended positive controls: 293T, A431, H1299, HeLa, Molt-4, Raji. Predicted reactivity: Mouse (97%), Rat (96%), Bovine (88%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

MAPK11 (p38 beta) is a serine/threonine kinase which is involved in a variety of cellular processes, and is activated by proinflammatory cytokines and environmental stress. Mitogen-activated protein kinase 11. The protein encoded by p38 MAPK beta is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.