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Description
The pannexin gene family encodes a second class of putative gap junction proteins and are highly conserved in invertebrates and mammals. Pannexins (Panx) are four-pass transmembrane proteins that oligomerize to form large pore ion and metabolite-permeable channels. Pannexin-1 (PANX1) and Pannexin-3 are closely related, while Pannexin-2 is a more distant relation. PANX1 is a transmembrane protein that forms a mechanosensitive ATP-permeable channel between adjacent cells and in the endoplasmic reticulum. PANX1 may play a role as a Ca2+ -leak channel to regulate ER Ca2+ homeostasis and regulates neural stem and progenitor cell proliferation.
Specifications
Specifications
| Antígeno | PANX1 |
| Aplicaciones | Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot |
| Clasificación | Polyclonal |
| Concentración | 0.14 mg/mL |
| Conjugado | Unconjugated |
| Formulación | PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 |
| génica | PANX1 |
| N.º de referencia del gen | Q96RD7 |
| Alias de gen | MRS1, pannexin 1, PANX1, PX1, UNQ2529 |
| Símbolos de los genes | PANX1 |
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Product Title
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