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PAPPA Monoclonal Antibody (PAPP A 1-24), Invitrogen™
Mouse Monoclonal Antibody
Marca: Invitrogen ABS0062402
Detalles adicionales : Peso : 0.01000kg
Descripción
ABS 006-24-02 detects native Pregnancy-associated plasma protein A (PAPP-A) from human samples. Heat and SDS denatured PAPP-A is also recognized, but not acid treated PAPP-A. ABS 006-24-02 has been successfully used in Western blotting, Immunohistochemistry and ELISA procedures. By Western blot, only unreduced forms of PAPA-A can be detected. In sandwich ELISA the optimal combination was BTE 004-09-02 as coating and biotinylated ABS 006-24-02 as detection. ABS 006-24-02 give the strongest singal in IHC compared to ABS 006-01-02 and BTE 004-09-02. The epitope of ABS 006-24-02 is different from BTE 004-09-02 and ABS 006-01-02. The epitope is located on the PAPP-A subunit of the heterotetramer. NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL
Pregnancy-associated plasma protein-A (PAPP-A, Insulin-like growth factor binding protein-4 protease, PAPP-A-proMBP complex) is a large heterottetrameric glycoprotein of approximately 500 kDa, which was first discovered in serum from pregnant women. The hetreotetramer consists of two PAPP-A subunits and two proMBP subunits. Low maternal serum levels of PAPP-A in first trimester biochemical screening is used as a marker of Down's syndrome (trisomy 21).Especificaciones
PAPPA | |
Monoclonal | |
0.92 mg/mL | |
PBS with 15mM sodium azide; pH 7.4 | |
Q13219 | |
PAPPA | |
Purified human PAPP-A. | |
400 μL | |
Primary | |
Human | |
Antibody | |
IgG1 κ |
ELISA, Immunohistochemistry (Paraffin), Western Blot | |
PAPP A 1-24 | |
Unconjugated | |
PAPPA | |
8430414N03Rik; ASBABP2; aspecific BCL2 ARE-binding protein 2; differentially placenta 1 expressed protein; DIPLA1; IGFBP-4 ase; IGFBP-4ase; IGF-dependent IGFBP-4 protease; insulin-like growth factor-dependent IGF binding protein-4 protease; insulin-like growth factor-dependent IGF-binding protein 4 protease; PAG1; PAPA; PAPP A; PAPPA; PAPP-A; PAPPA1; Pappalysin; pappalysin 1; pappalysin-1; pregnacy-associated plasma protein A; pregnancy-associated plasma protein A; pregnancy-associated plasma protein A, pappalysin 1; RP11-45A16.1 | |
Mouse | |
Protein A | |
RUO | |
5069 | |
4° C, store in dark | |
Liquid |