DiscoverX PathHunter™ eXpress ACVR1C/ACVR2B Dimerization Assay

The PathHunter™ ACVR1C/ACVR2B Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand (e.g. activin B) induced dimerization of ACVR1C/ACVR2B receptors. This product uses EFC technology. The cell line included overexpresses ACVR2B target protein fused to PK alongside ACVR1C target protein fused to EA. Upon ligand-induced dimerization of ACVR1C/ACVR2B , detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.