STEMCELL Technologies Phorbol 12-myristate 13-acetate

PKC pathway activator; Activates protein kinase C

Marca: STEMCELL Technologies 74042

Código de producto. 17160312

Por favor, inicie sesión para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo.

Este artículo no se puede devolver. Vea la política de devoluciones

Descripción

Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is a reversible, highly potent activator of protein kinase C (PKC), including Group A and Group B isoforms (Blumberg)
PMA activates PKC isoforms through the binding of the C1 domain (Hurley et al.) PMA can also activate certain mitogen-activated protein (MAP) kinase pathways through PKC (Adams & Parker)
Stimulates cardiac differentiation of mesenchymal stem cells (Seo et al.)
Promotes hematopoietic differentiation (Clemens et al.)
Stimulates differentiation of IL-15-stimulated lamina propria CD4+ T cells into CXCR5+CD4+ cells when used together with ionomicin (Sarra et al.)
In combination with AS101, it shows anti-leukemic activity and stimulates human leukemia cell lines to differentiate into macrophage-like cells (Glesne & Huberman; Hayun et al.)

Especificaciones

Sinónimo	12-O-Tetradecanoylphorbol-13-acetate; PMA; TPA
Fórmula molecular	C₃₆H₅₆O₈

Sugerencias de productos

Descripción