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Invitrogen™ Phospho-Rb (Ser807, Ser811) Recombinant Rabbit Monoclonal Antibody (13H27L9)
Rabbit Recombinant Monoclonal Antibody
Marca: Invitrogen™ 702097
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Descripción
This antibody is predicted to react with Monkey, Bovine, Pig Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.
Especificaciones
| Phospho-Rb (Ser807, Ser811) | |
| Recombinant Monoclonal | |
| 0.5 mg/mL | |
| PBS with 0.09% sodium azide; pH 7.4 | |
| P06400 | |
| RB1 | |
| Peptide corresponding to human Phospho-Rb (Ser807/Ser811) [aa805-aa814]. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
| Western Blot, Immunocytochemistry | |
| 13H27L9 | |
| Unconjugated | |
| RB1 | |
| Cleaved Rb; delta RB-p70; DRb-p70; exon 17 tumor GOS561 substitution mutation causes premature stop; GOS563 exon 17 substitution mutation causes premature stop; OSRC; p104; p104 chicken Rb; P105RB; p105-Rb; Phospho-Retinoblastoma; pp105; pp110; PPP1R130; pRb; prepro-retinoblastoma-associated protein; protein phosphatase 1, regulatory subunit 130; rb; RB transcriptional corepressor 1; RB1; Rb-1; Rb-p70; Retin; Retinoblastoma; retinoblastoma 1; retinoblastoma 1 (including osteosarcoma); retinoblastoma 1 protein; retinoblastoma gene; retinoblastoma isoform A; retinoblastoma protein; retinoblastoma suspectibility protein; retinoblastoma tumor suppressor; retinoblastoma-associated protein | |
| Rabbit | |
| Protein A | |
| RUO | |
| 5925 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
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