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Eurofins DiscoverX Pim1 Protein, Active
Descripción
Protein serine/threonine kinase PIM1 (pim-1-oncogene) is a member of a small family of highly homologous kinases, including PIM1, PIM2, and PIM3, and all members are expressed in the thymus. Overexpression of each of these members can promote lymphomagenesis in mice. PIM1 associates with Myb and phosphorylates the Myb DNA binding domain, suggesting that it regulates Myb protein activity by direct phosphorylation. Recently four proto-oncogenes PIM1, cMYC, PAX-5 and RhoH/TTF were found hypermutated in diffuse large B cell lymphoma (DLBCL) with >50% of cases carrying at least two mutated genes.
GenBank M27903
Especificaciones
Especificaciones
| Formulación | mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 0.1 mM EGTA, 150 mM NaCl, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. |
| Peso molecular | 62 kDa |
| Cantidad | 250 μg |
| Especie | Human |
| Recombinante | Recombinant |
| Etiqueta de proteína | N-terminal GST |
| Sistema de expresión | Recombinant enzyme expressed in E. coli cells |
| Forma de proteína | Full-length |
| Grado de pureza o calidad | ≥73% |
| Expresión | Pim-1, active |
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