Learn More
Eurofins DiscoverX Pim1 Protein, Active
Active, N-terminal GST-tagged recombinant human full length Pim-1, for use in Kinase Assays.
Marca: Eurofins DiscoverX 14-573
Descripción
Protein serine/threonine kinase PIM1 (pim-1-oncogene) is a member of a small family of highly homologous kinases, including PIM1, PIM2, and PIM3, and all members are expressed in the thymus. Overexpression of each of these members can promote lymphomagenesis in mice. PIM1 associates with Myb and phosphorylates the Myb DNA binding domain, suggesting that it regulates Myb protein activity by direct phosphorylation. Recently four proto-oncogenes PIM1, cMYC, PAX-5 and RhoH/TTF were found hypermutated in diffuse large B cell lymphoma (DLBCL) with >50% of cases carrying at least two mutated genes.
GenBank M27903
Especificaciones
mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 0.1 mM EGTA, 150 mM NaCl, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. | |
10 μg | |
Recombinant | |
Recombinant enzyme expressed in E. coli cells | |
≥73% |
62 kDa | |
Human | |
N-terminal GST | |
Full-length | |
Pim-1, active |
El Programa Encompass de Fisher Scientific ofrece artículos que no forman parte de nuestra cartera de distribución. Estos productos no suelen tener imágenes ni descripciones detalladas. Sin embargo, nos comprometemos a mejorar su experiencia de compra. Utilice el siguiente formulario para hacernos llegar sus comentarios sobre el contenido de este producto.