PRMT6 Monoclonal Antibody (4G2), Invitrogen™

Descripción

MA5-15584 targets PRMT6 in indirect ELISA, WB applications and shows reactivity with Human and Non-human primate samples. The MA5-15584 immunogen is purified recombinant fragment of human PRMT6 expressed in E. Coli. <br>. MA5-15584 detects PRMT6 which has a predicted molecular weight of approximately 42kDa.

Protein arginine N-methyltransferase 6 (PRMT6) PRMT6 demonstrates type I PRMT activity, capable of forming both omega-N monomethylarginine and asymmetric dimethylarginine derivatives on the recombinant glycine- and arginine-rich substrates. cts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7.